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THE FUTURE OF IN VITRO FERTILIZATION
 
The Social Problems Facing In Vitro Fertilization (IVF)
 
Each year nearly 40,000 children in the U.S. are born through In Vitro Fertilization procedures. Unfortunately, IVF leads to multiple births (twins, triplets, or more) born at 10 times the natural rate. Numerous studies have shown the many health issues associated with multiple births, even if just limited to twins. US couples alone face nearly $600MM annually in neonatal costs associated with IVF multiple births.
 
 
The Reason Behind High Multiple Birth Rates
 
The source of the problem is simple: fertility clinics rely on the transfer of multiple embryos in an attempt to raise success outcomes. When pregnancy does occur, multiple births result in 35% of all IVF procedures.
 
Two key factors drive IVF clinics to continue with this practice: high out of pocket costs for infertile couples and relatively low IVF success outcomes. Low success outcomes are particularly common for couples in their late 30’s. Because IVF is not typically covered by insurance plans, infertile couples demand that clinics use whatever means possible to achieve pregnancy. Thus, the combination of high out-of-pocket costs and low success probabilities leaves fertility clinics with few alternatives other than to transfer multiple embryos for each IVF cycle.
 
Incept: Transforming the Future of IVF
 
Incept’s PinFlo platform will enable a true transformation within IVF - bringing the first easy-to-use clinical platform ideal for sperm isolation, non-invasive insemination with just a few sperm, in vivo-like culture conditions, powerful nano and microscale embryo analysis, and precise embryo cryopreservation capabilities.
 
Finally, embryologists will be able to eliminate the conditions that can suboptimize an embryo’s success potential throughout an IVF cycle. Even more importantly, these same tools will also standardize and automate assays and procedures to improve how clinics predict embryo viability and to preserve unused embryos for later cycles. Collectively, these technologies will enable the highest potential for a successful pregnancy from a single embryo transfer and thus virtually eliminate the incidence of multiple births (twins, triplets, etc).
 
By eliminating the many different points of inefficiency, fertility specialists will now be able to assure patients with confidence that at every point in the IVF process they have maximized a couple’s opportunity for success.
 
 
 

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  PUBLICATIONS AND RESEARCH
 
 
 
  Computerized microfluidic cell culture using elastomeric channels and Braille displays.  
 
  Computer-controlled microcirculatory support system for endothelial cell culture and shearing.  
 
  Handheld recirculation system and customized media for microfluidic cell culture  
 
  Rethinking Gamete/Embryo Isolation and Culture with Microfluidics  
 
  Isolation of Motile Spermatozoa from Semen Samples Using Microfluidics  
 

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