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Finally, a Breakthrough for Better Embryo Development. |
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Incept’s PinFlo™ technology platform delivers a cell culture system that can mimic in vivo conditions. The PinFlo platform is designed to be the first microfluidic system that will address the demanding user requirements of fertility professionals while reproducing physiologic conditions ideal for embryo and oocyte culture in the Assisted Reproduction lab. With these new capabilities, fertility clinics will now have powerful new alternatives to improve the quality of care for patients undergoing in vitro fertilization. |
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Premium Cell Culture Made Simple
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| Incept’s PinFlo™ technology platform delivers the first ever easy-to-use cell culture system that closely mimics microscale physiologic conditions ideal for managing the culture of premium cells. Due to their high sensitivity to in vitro conditions, premium cells typically are the most expensive to sustain and difficult to manage in macroscale culture conditions. Even small improvements in premium cell behavior can lead to significant gains in clinical value. There is a growing need within cell biology for a simple way to create and control conditions to close the gap between the current in vitro standards and in vivo conditions |
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| The
PinFlo system controls fluids more easily and with more
flexibility than any known system. Using its patent-pending
array of tiny actuated pins, the software controlled PinFlo
generates peristaltic flow and valving by pressing the pins
into specially modified “chips”. |
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Unlike other attempts to bring the power of microfluidics to
market that usually begin with complex chip design, Incept’s
mission was to create an infinitely flexible and
reconfigurable fluidic control platform as its starting point.
The result - flow and mixing conditions can be created,
modified, and changed wherever, and whenever, the user
desires, on demand. Now, instead of long development cycles to
create new chip applications because the flow conditions
cannot be easily modified, new chip design can be achieved in
rapid succession. |
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On Demand Control:
Physiological Conditions "On the Fly" |
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Incept believes that
any technology must minimize operating knowledge requirements
so that clinicians can focus on what is
important: generating improved cell and embryo performance
only possible in dynamic culture environments. |
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Our “On-Demand”
system capabilities allow users to change physiologic
conditions on the fly. Whether users require changes in flow
rate, mixing routines, gradient conditions, or media, the
PinFlo software (patent pending) gives users the capability to
easily and instantaneously control and manipulate nano or
micro scale conditions on-demand. The above videos demonstrate
real time images of the PinFlo in action. |
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Microcirculation
Capabilities |
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While some devices,
such as standard peristaltic or syringe pumps, may be able to
replicate one or two specific conditions, the PinFlo is the
first to provide users the full array of options with a single
device. |
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PinFlo capabilities include:
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Continuous and
Instantaneous Shear Stress
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Temporal and Spatial
Gradient Creation
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Long-Term Dynamic
Cell Culture
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Fluidic
Mixing
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High Density Culture
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Co-Culture
Environments
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Flow Types: |
Pulsatile |
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Fluidic Flow Capabilities: |
Laminar, Mixed, Segmented |
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Flow Duration Potential: |
Seconds to Weeks |
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Channel Scale: |
Typical 20
μm
to 500
μm |
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Stream Size: |
10-100 μm |
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Average Shear Stress Potential: |
<1dyn/cm˛ to 15dyn/cm˛ |
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Cell Types Cultured to Date: |
Mouse Embryo, Myoblasts, Endothelial cells, osteoblasts,
epithelial cells |
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Pump Frequency: |
0-10 Hz |
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PUBLICATIONS AND RESEARCH |
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